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Generation of reactive oxygen species by fungal NADPH oxidases is required for rice blast disease.


ABSTRACT: One of the first responses of plants to microbial attack is the production of extracellular superoxide surrounding infection sites. Here, we report that Magnaporthe grisea, the causal agent of rice blast disease, undergoes an oxidative burst of its own during plant infection, which is associated with its development of specialized infection structures called appressoria. Scavenging of these oxygen radicals significantly delayed the development of appressoria and altered their morphology. We targeted two superoxide-generating NADPH oxidase-encoding genes, Nox1 and Nox2, and demonstrated genetically, that each is independently required for pathogenicity of M. grisea. Deltanox1 and Deltanox2 mutants are incapable of causing plant disease because of an inability to bring about appressorium-mediated cuticle penetration. The initiation of rice blast disease therefore requires production of superoxide by the invading pathogen.

SUBMITTER: Egan MJ 

PROVIDER: S-EPMC1913907 | biostudies-other | 2007 Jul

REPOSITORIES: biostudies-other

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Generation of reactive oxygen species by fungal NADPH oxidases is required for rice blast disease.

Egan Martin J MJ   Wang Zheng-Yi ZY   Jones Mark A MA   Smirnoff Nicholas N   Talbot Nicholas J NJ  

Proceedings of the National Academy of Sciences of the United States of America 20070628 28


One of the first responses of plants to microbial attack is the production of extracellular superoxide surrounding infection sites. Here, we report that Magnaporthe grisea, the causal agent of rice blast disease, undergoes an oxidative burst of its own during plant infection, which is associated with its development of specialized infection structures called appressoria. Scavenging of these oxygen radicals significantly delayed the development of appressoria and altered their morphology. We targ  ...[more]

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