Ontology highlight
ABSTRACT:
SUBMITTER: Borsotti C
PROVIDER: S-EPMC1924485 | biostudies-other | 2007 Jul
REPOSITORIES: biostudies-other
Borsotti Chiara C Franklin Anna R K AR Lu Sydney X SX Kim Theo D TD Smith Odette M OM Suh David D King Chris G CG Chow Andrew A Liu Chen C Alpdogan Onder O van den Brink Marcel R M MR
Blood 20070329 2
Tumor necrosis factor (TNF) plays an important role in graft-versus-host disease (GVHD) and graft-versus-tumor (GVT) activity after allogeneic bone marrow transplantation (allo-BMT). TNF can be expressed in a membrane-bound form (memTNF) and as a soluble (solTNF) molecule after being cleaved by the TNF-alpha converting enzyme (TACE). To study the contribution of donor T-cell-derived memTNF versus solTNF in GVHD and GVT, we used mice containing a noncleavable allele in place of endogenous TNF (me ...[more]