Dataset Information
A new tetracycline resistance determinant, Tet H, from Pasteurella multocida specifying active efflux of tetracycline.
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ABSTRACT:
SUBMITTER: Hansen LM
PROVIDER: S-EPMC192782 | biostudies-other | 1993 Dec
REPOSITORIES: biostudies-other
Publications
A new tetracycline resistance determinant, Tet H, from Pasteurella multocida specifying active efflux of tetracycline.
Antimicrobial agents and chemotherapy 19931201 12
The tetracycline resistance determinant on plasmid pVM111 from an avian strain of Pasteurella multocida mediates tetracycline resistance by a regulated active efflux mechanism. DNA coding for the determinant did not hybridize at high stringency with DNA representing a group of common tetracycline resistance determinants. The DNA sequence, however; revealed a structural gene and a repressor gene which had significant (37 to 64%) sequence similarities with previously described classes of efflux-ty ...[more]