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A new tetracycline resistance determinant, Tet H, from Pasteurella multocida specifying active efflux of tetracycline.

ABSTRACT: The tetracycline resistance determinant on plasmid pVM111 from an avian strain of Pasteurella multocida mediates tetracycline resistance by a regulated active efflux mechanism. DNA coding for the determinant did not hybridize at high stringency with DNA representing a group of common tetracycline resistance determinants. The DNA sequence, however; revealed a structural gene and a repressor gene which had significant (37 to 64%) sequence similarities with previously described classes of efflux-type tetracycline resistance genes from members of the family Enterobacteriaceae. The new determinant has been assigned to class H.

SUBMITTER: Hansen LM

PROVIDER: S-EPMC192782 | biostudies-other | 1993 Dec

REPOSITORIES: biostudies-other

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A new tetracycline resistance determinant, Tet H, from Pasteurella multocida specifying active efflux of tetracycline.

Hansen L M LM McMurry L M LM Levy S B SB Hirsh D C DC

Antimicrobial agents and chemotherapy 19931201 12

The tetracycline resistance determinant on plasmid pVM111 from an avian strain of Pasteurella multocida mediates tetracycline resistance by a regulated active efflux mechanism. DNA coding for the determinant did not hybridize at high stringency with DNA representing a group of common tetracycline resistance determinants. The DNA sequence, however; revealed a structural gene and a repressor gene which had significant (37 to 64%) sequence similarities with previously described classes of efflux-ty ...[more]

PMID: 8109938

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