Antifungal hydrogels.
Ontology highlight
ABSTRACT:
SUBMITTER: Zumbuehl A
PROVIDER: S-EPMC1941801 | biostudies-other | 2007 Aug
REPOSITORIES: biostudies-other
Publications
Antifungal hydrogels.
Zumbuehl Andreas A Ferreira Lino L Kuhn Duncan D Astashkina Anna A Long Lisa L Yeo Yoon Y Iaconis Tiffany T Ghannoum Mahmoud M Fink Gerald R GR Langer Robert R Kohane Daniel S DS
Proceedings of the National Academy of Sciences of the United States of America 20070730 32
Fungi are increasingly identified as major pathogens in bloodstream infections, often involving indwelling devices. Materials with antifungal properties may provide an important deterrent to these infections. Here we describe amphogel, a dextran-based hydrogel into which amphotericin B is adsorbed. Amphogel kills fungi within 2 h of contact and can be reused for at least 53 days without losing its effectiveness against Candida albicans. The antifungal material is biocompatible in vivo and does n ...[more]
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