Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC1941824 | biostudies-other | 2007 Aug
REPOSITORIES: biostudies-other
Zhao Yangu Y Kwan Kin-Ming KM Mailloux Christina M CM Lee Woon-Kyu WK Grinberg Alexander A Wurst Wolfgang W Behringer Richard R RR Westphal Heiner H
Proceedings of the National Academy of Sciences of the United States of America 20070730 32
Purkinje cells are one of the major types of neurons that form the neural circuitry in the cerebellum essential for fine control of movement and posture. During development, Purkinje cells also are critically involved in the regulation of proliferation of progenitors of granule cells, the other major type of neurons in the cerebellum. The process that controls differentiation of Purkinje cells from their early precursors is poorly understood. Here we report that two closely related LIM-homeobox ...[more]