Selective inhibition of thromboxane B2 accumulation and metabolism in perfused guinea-pig lung.
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ABSTRACT:
SUBMITTER: Hoult JR
PROVIDER: S-EPMC2044786 | biostudies-other | 1983 Jan
REPOSITORIES: biostudies-other
Publications
Selective inhibition of thromboxane B2 accumulation and metabolism in perfused guinea-pig lung.
British journal of pharmacology 19830101 1
1 U46619, a prostaglandin H2 endoperoxide analogue and thromboxane A2 agonist, dose-dependently inhibited accumulation and metabolism of thromboxane B2 in the isolated perfused lung of the guinea-pig. At similar doses prostaglandins E1, E2, F1 alpha, F2 alpha, I2, 5, 6-trans-PGE2 and 8-iso-PGE1 were ineffective. 2 U46619 did not affect accumulation and metabolism of prostaglandin F2 alpha under similar conditions. 3 The pulmonary disposition of thromboxane B2, which occurs by uptake into pulmona ...[more]
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