GyrB mutations in coumermycin A1-resistant Borrelia burgdorferi.
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ABSTRACT:
SUBMITTER: Samuels DS
PROVIDER: S-EPMC205466 | biostudies-other | 1994 May
REPOSITORIES: biostudies-other
Publications
gyrB mutations in coumermycin A1-resistant Borrelia burgdorferi.
Samuels D S DS Marconi R T RT Huang W M WM Garon C F CF
Journal of bacteriology 19940501 10
We have isolated and characterized mutants of Borrelia burgdorferi that are resistant to the antibiotic coumermycin A1, which targets the B subunit of DNA gyrase. Mutants had either 100- or 300-fold higher resistance to coumermycin A1 than wild-type B. burgdorferi. In each case, a single point mutation in the gyrB gene converted Arg-133 to Gly or Ile. Mutations in the homologous Arg residue of Escherichia coli DNA gyrase are also associated with resistance to coumarin antimicrobial agents. ...[more]
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