Cloning and analysis of a locus (mcr) involved in mitomycin C resistance in Streptomyces lavendulae.
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ABSTRACT:
SUBMITTER: August PR
PROVIDER: S-EPMC205660 | biostudies-other | 1994 Jul
REPOSITORIES: biostudies-other
Publications
Cloning and analysis of a locus (mcr) involved in mitomycin C resistance in Streptomyces lavendulae.
August P R PR Flickinger M C MC Sherman D H DH
Journal of bacteriology 19940701 14
Two genes (mcrA and mcrB) from Streptomyces lavendulae that together confer resistance to mitomycin C were identified. This DNA appears to comprise a polycistronic operon with a drug-inducible leaderless mRNA. The deduced amino acid sequence of mcrA shows similarity to sequences of a special class of bacterial, plant, and animal oxygen oxidoreductases. ...[more]
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