Tau expression in model adenocarcinomas correlates with docetaxel sensitivity in tumour-bearing mice.
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ABSTRACT:
SUBMITTER: Veitia R
PROVIDER: S-EPMC2063126 | biostudies-other | 1998 Oct
REPOSITORIES: biostudies-other
Publications
Tau expression in model adenocarcinomas correlates with docetaxel sensitivity in tumour-bearing mice.
Veitia R R Bissery M C MC Martinez C C Fellous A A
British journal of cancer 19981001 7
Docetaxel is a new taxoid with clinical activity in breast and lung cancer. Using docetaxel-sensitive and -refractory mammary and pancreatic murine tumours, as well as human-derived neoplasms, we investigated if a determinant of docetaxel sensitivity could be found at the level of its mechanism of action. Because microtubules represent the cellular targets of the drug, we studied their heterogeneity in the tumour models to try to explain the differences in drug sensitivity. Reverse transcription ...[more]
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2017-03-27 | GSE93636 | GEO
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