Ontology highlight
ABSTRACT:
SUBMITTER: Poncet D
PROVIDER: S-EPMC2064390 | biostudies-other | 2006 Sep
REPOSITORIES: biostudies-other
Poncet Delphine D Pauleau Anne-Laure AL Szabadkai Gyorgy G Vozza Angelo A Scholz Sebastian R SR Le Bras Morgane M Brière Jean-Jacques JJ Jalil Abdelali A Le Moigne Ronan R Brenner Catherine C Hahn Gabriele G Wittig Ilka I Schägger Hermann H Lemaire Christophe C Bianchi Katiuscia K Souquère Sylvie S Pierron Gerard G Rustin Pierre P Goldmacher Victor S VS Rizzuto Rosario R Palmieri Ferdinando F Kroemer Guido G
The Journal of cell biology 20060918 7
Replication of human cytomegalovirus (CMV) requires the expression of the viral mitochondria-localized inhibitor of apoptosis (vMIA). vMIA inhibits apoptosis by recruiting Bax to mitochondria, resulting in its neutralization. We show that vMIA decreases cell size, reduces actin polymerization, and induces cell rounding. As compared with vMIA-expressing CMV, vMIA-deficient CMV, which replicates in fibroblasts expressing the adenoviral apoptosis suppressor E1B19K, induces less cytopathic effects. ...[more]