Ontology highlight
ABSTRACT:
SUBMITTER: Toone WM
PROVIDER: S-EPMC207940 | biostudies-other | 1991 Jun
REPOSITORIES: biostudies-other
Journal of bacteriology 19910601 11
We have cloned and sequenced a new gene from Escherichia coli which encodes a 64-kDa protein. The inferred amino acid sequence of the protein shows remarkable similarity to eIF4A, a murine translation initiation factor that has an ATP-dependent RNA helicase activity and is a founding member of the D-E-A-D family of proteins (characterized by a conserved Asp-Glu-Ala-Asp motif). Our new gene, called deaD, was cloned as a gene dosage-dependent suppressor of temperature-sensitive mutations in rpsB, ...[more]