Ontology highlight
ABSTRACT:
SUBMITTER: Yang SY
PROVIDER: S-EPMC2118177 | biostudies-other | 2006 Dec
REPOSITORIES: biostudies-other
Yang Shu Yuan SY Fugmann Sebastian D SD Schatz David G DG
The Journal of experimental medicine 20061218 13
It is thought that gene conversion (GCV) and somatic hypermutation (SHM) of immunoglobulin (Ig) genes occur in two steps: the generation of uracils in DNA by activation-induced cytidine deaminase, followed by their subsequent repair by various DNA repair pathways to generate sequence-diversified products. It is not known how either of the two steps is targeted specifically to Ig loci. Because of the tight link between transcription and SHM, we have investigated the role of endogenous Ig light ch ...[more]