Ontology highlight
ABSTRACT:
SUBMITTER: Petkova SB
PROVIDER: S-EPMC2118221 | biostudies-other | 2006 Feb
REPOSITORIES: biostudies-other
Petkova Stefka B SB Konstantinov Konstantin N KN Sproule Thomas J TJ Lyons Bonnie L BL Awwami Moheeb Al MA Roopenian Derry C DC
The Journal of experimental medicine 20060213 2
Rheumatoid arthritis (RA) is a complex autoimmune disease with a poorly understood pathogenesis. The disease is associated with polyclonal B cell activation and the production of autoantibodies (autoAbs), but there is a longstanding controversy as to whether such Abs contribute to, or are secondary to, the pathogenesis of RA. To address the potential pathogenicity of human RA-associated Abs, we developed a passive transfer model involving mice deficient in the low-affinity inhibitory Fc receptor ...[more]