Ontology highlight
ABSTRACT:
SUBMITTER: Kaneko Y
PROVIDER: S-EPMC2118246 | biostudies-other | 2006 Mar
REPOSITORIES: biostudies-other
Kaneko Yoshikatsu Y Nimmerjahn Falk F Madaio Michael P MP Ravetch Jeffrey V JV
The Journal of experimental medicine 20060306 3
Introduction of heterologous anti-glomerular basement membrane antiserum (nephrotoxic serum, NTS) into presensitized mice triggers the production of IgG anti-NTS antibodies that are predominantly IgG2b and the glomerular deposition of pathogenic immune complexes, leading to accelerated renal disease. The pathology observed in this model is determined by the effector cell activation threshold that is established by the coexpression on infiltrating macrophages of the IgG2a/2b restricted activation ...[more]