Ontology highlight
ABSTRACT:
SUBMITTER: Sawa S
PROVIDER: S-EPMC2118324 | biostudies-other | 2006 Jun
REPOSITORIES: biostudies-other
Sawa Shin-ichiro S Kamimura Daisuke D Jin Gui-Hua GH Morikawa Hideyuki H Kamon Hokuto H Nishihara Mika M Ishihara Katsuhiko K Murakami Masaaki M Hirano Toshio T
The Journal of experimental medicine 20060522 6
Mice homozygous for the F759 mutation in the gp130 interleukin (IL)-6 receptor subunit have enhanced gp130-mediated signal transducer and activator of transcription (STAT)3 activation and spontaneously developed a lymphocyte-mediated rheumatoid arthritis-like joint disease. Here, we show that the development of the disease is dependent on both major histocompatibility complex (MHC) II-restricted CD4+ T cells and IL-6 family cytokines. In spite of the necessity for CD4+ T cells, the gp130 mutatio ...[more]