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A constant affinity threshold for T cell tolerance.

ABSTRACT: T cell tolerance depends on the T cell receptor's affinity for peptide/major histocompatibility complex (MHC) ligand; this critical parameter determines whether a thymocyte will be included (positive selection) or excluded (negative selection) from the T cell repertoire. A quantitative analysis of ligand binding was performed using an experimental system permitting receptor-coreceptor interactions on live cells under physiological conditions. Using three transgenic mouse strains expressing distinct class I MHC-restricted T cell receptors, we determined the affinity that defines the threshold for negative selection. The affinity threshold for self-tolerance appears to be a constant for cytotoxic T lymphocytes.

SUBMITTER: Naeher D 

PROVIDER: S-EPMC2118488 | biostudies-other | 2007 Oct

REPOSITORIES: biostudies-other

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A constant affinity threshold for T cell tolerance.

Naeher Dieter D   Daniels Mark A MA   Hausmann Barbara B   Guillaume Philippe P   Luescher Immanuel I   Palmer Ed E  

The Journal of experimental medicine 20071015 11

T cell tolerance depends on the T cell receptor's affinity for peptide/major histocompatibility complex (MHC) ligand; this critical parameter determines whether a thymocyte will be included (positive selection) or excluded (negative selection) from the T cell repertoire. A quantitative analysis of ligand binding was performed using an experimental system permitting receptor-coreceptor interactions on live cells under physiological conditions. Using three transgenic mouse strains expressing disti  ...[more]