Ontology highlight
ABSTRACT:
SUBMITTER: Rudy CK
PROVIDER: S-EPMC2119259 | biostudies-other | 1992 Jun
REPOSITORIES: biostudies-other
Rudy C K CK Kraus E E Palmer E E Huber B T BT
The Journal of experimental medicine 19920601 6
Mls-1 is an endogenous superantigen that leads to in vivo deletion and in vitro stimulation of T cell receptor (TCR) V beta 6-, 7-, 8.1-, and 9-expressing cells. The MA/MyJ mouse deletes the identical set of TCR from its mature T cell repertoire; however, it does not contain Mtv-7, the murine mammary tumor provirus (MMTV), whose sag gene encodes Mls-1. Interestingly, the superantigen activity of this mouse strain segregates with a new mammary tumor provirus, Mtv-43, not seen in other inbred stra ...[more]