Ontology highlight
ABSTRACT:
SUBMITTER: Hulsken J
PROVIDER: S-EPMC2120290 | biostudies-other | 1994 Dec
REPOSITORIES: biostudies-other
Hülsken J J Birchmeier W W Behrens J J
The Journal of cell biology 19941201 6 Pt 2
beta-Catenin is involved in the formation of adherens junctions of mammalian epithelia. It interacts with the cell adhesion molecule E-cadherin and also with the tumor suppressor gene product APC, and the Drosophila homologue of beta-catenin, armadillo, mediates morphogenetic signals. We demonstrate here that E-cadherin and APC directly compete for binding to the internal, armadillo-like repeats of beta-catenin; the NH2-terminal domain of beta-catenin mediates the interaction of the alternative ...[more]