Ontology highlight
ABSTRACT:
SUBMITTER: Xiao X
PROVIDER: S-EPMC2141820 | biostudies-other | 2007 Nov
REPOSITORIES: biostudies-other
Xiao Xinshu X Wang Zefeng Z Jang Minyoung M Burge Christopher B CB
Proceedings of the National Academy of Sciences of the United States of America 20071112 47
Accurate and efficient splicing of eukaryotic pre-mRNAs requires recognition by trans-acting factors of a complex array of cis-acting RNA elements. Here, we developed a generalized Bayesian network to model the coevolution of splicing cis elements in diverse eukaryotic taxa. Cross-exon but not cross-intron compensatory interactions between the 5' splice site (5'ss) and 3' splice site (3'ss) were observed in human/mouse, indicating that the exon is the primary evolutionary unit in mammals. Studie ...[more]