A quantitative methodology for the de novo design of proteins.
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ABSTRACT:
SUBMITTER: Brenner SE
PROVIDER: S-EPMC2142604 | biostudies-other | 1994 Oct
REPOSITORIES: biostudies-other
Publications
A quantitative methodology for the de novo design of proteins.
Protein science : a publication of the Protein Society 19941001 10
We have developed a general quantitative methodology for designing proteins de novo, which automatically produces sequences for any given plausible protein structure. The method incorporates statistical information, a theoretical description of protein structure, and motifs described in the literature. A model system embodying a portion of the quantitative methodology has been used to design many protein sequences for the phage 434 Cro and fibronectin type III domain folds, as well as several ot ...[more]
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