TRIADs: a new class of proteins with a novel cysteine-rich signature.
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ABSTRACT:
SUBMITTER: van der Reijden BA
PROVIDER: S-EPMC2144383 | biostudies-other | 1999 Jul
REPOSITORIES: biostudies-other
Publications
TRIADs: a new class of proteins with a novel cysteine-rich signature.
van der Reijden B A BA Erpelinck-Verschueren C A CA Löwenberg B B Jansen J H JH
Protein science : a publication of the Protein Society 19990701 7
Triad1 was recently identified as a nuclear RING finger protein, which is up-regulated during retinoic acid induced granulocytic differentiation of acute leukemia cells. Here we show that a cysteine-rich domain (C6HC), present in Triad1, is conserved in at least 24 proteins encoded by various eukaryotes. The C6HC consensus pattern C-x(4)-C-x(14-30)-C-x(1-4)-C-x(4)-C-x(2)-C-x(4)-H-x(4)-C defines this structure as the fourth family member of the zinc-binding RING, LIM, and LAP/PHD fingers. Strikin ...[more]
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