Ontology highlight
ABSTRACT:
SUBMITTER: Yuan C
PROVIDER: S-EPMC2144649 | biostudies-other | 2000 Jun
REPOSITORIES: biostudies-other
Yuan C C Selby T L TL Li J J Byeon I J IJ Tsai M D MD
Protein science : a publication of the Protein Society 20000601 6
Within the tumor suppressor protein INK4 (inhibitor of cyclin-dependent kinase 4) family, p15INK4B is the smallest and the only one whose structure has not been determined previously, probably due to the protein's conformational flexibility and instability. In this work, multidimensional NMR studies were performed on this protein. The first tertiary structure was built by comparative modeling with p16INK4A as the template, followed by restrained energy minimization with NMR constraints (NOE and ...[more]