Ontology highlight
ABSTRACT:
SUBMITTER: van Breugel M
PROVIDER: S-EPMC2172899 | biostudies-other | 2003 Apr
REPOSITORIES: biostudies-other
The Journal of cell biology 20030401 2
The Dis1/XMAP215 family of microtubule-associated proteins conserved from yeast to mammals is essential for cell division. XMAP215, the Xenopus member of this family, has been shown to stabilize microtubules in vitro, but other members of this family have not been biochemically characterized. Here we investigate the properties of the Saccharomyces cerevisiae homologue Stu2p in vitro. Surprisingly, Stu2p is a microtubule destabilizer that binds preferentially to microtubule plus ends. Quantitativ ...[more]