Ontology highlight
ABSTRACT:
SUBMITTER: Okada A
PROVIDER: S-EPMC2189084 | biostudies-other | 1988 Oct
REPOSITORIES: biostudies-other
Okada A A Bank I I Rogozinski L L Takihara Y Y Mak T W TW Chess L L Alt F W FW
The Journal of experimental medicine 19881001 4
The CD3+, IL-2-dependent normal human thymocyte clone, CII, expresses on its surface a CD3-associated gamma/delta TCR. We have further elucidated the structure of this receptor from the nucleotide sequence of cDNA and genomic clones from CII that encode functional TCR-gamma and -delta chains. We find that the CII line expresses a C gamma 2 constant region that is a polymorphic form lacking a copy of an internal exon; the sequence of this constant region accounts for the size of the gamma chain a ...[more]