Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein.
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ABSTRACT:
SUBMITTER: Mucke L
PROVIDER: S-EPMC2191956 | biostudies-other | 1995 Apr
REPOSITORIES: biostudies-other
Publications
Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein.
Mucke L L Abraham C R CR Ruppe M D MD Rockenstein E M EM Toggas S M SM Mallory M M Alford M M Masliah E E
The Journal of experimental medicine 19950401 4
Expression of the HIV-1 envelope protein gp120 in brains of transgenic (tg) mice induces extensive neurodegeneration (Toggas, S. M., E. Masliah, E. M. Rockenstein, G. F. Rall, C. R. Abraham, and L. Mucke. 1994. Nature [Lond.]. 367:188-193.). To further analyze the pathogenesis of gp120-induced neurotoxicity and to assess the neuroprotective potential of human amyloid precursor proteins (hAPPs) in vivo, different hAPP isoforms were expressed in neurons of gp120/hAPP-bigenic mice: hAPP751, which c ...[more]
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