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Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis.

ABSTRACT: We have identified a serine/threonine kinase that is rapidly activated during Fas-mediated apoptosis. Fas-activated serine/threonine kinase (FAST) is phosphorylated on serine and threonine residues in Jurkat cells. In response to Fas ligation, it is rapidly dephosphorylated and concomitantly activated to phosphorylate TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Phosphorylation of TIA-1 precedes the onset of DNA fragmentation, suggesting a role in signaling downstream events in the apoptotic program. Our results introduce Fast and TIA-1 as components of a molecular cascade involved in signaling Fas-mediated apoptosis.

SUBMITTER: Tian Q

PROVIDER: S-EPMC2192163 | biostudies-other | 1995 Sep

REPOSITORIES: biostudies-other

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Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis.

Tian Q Q Taupin J J Elledge S S Robertson M M Anderson P P

The Journal of experimental medicine 19950901 3

We have identified a serine/threonine kinase that is rapidly activated during Fas-mediated apoptosis. Fas-activated serine/threonine kinase (FAST) is phosphorylated on serine and threonine residues in Jurkat cells. In response to Fas ligation, it is rapidly dephosphorylated and concomitantly activated to phosphorylate TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Phosphorylation of TIA-1 precedes the onset of DNA fragmentation, suggesting a role in si ...[more]

PMID: 7544399

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Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing.

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| S-EPMC2040905 | biostudies-literature

Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammation.

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The Serine/threonine kinase Stk33 exhibits autophosphorylation and phosphorylates the intermediate filament protein Vimentin.

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Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis.

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| S-EPMC85221 | biostudies-literature

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