Ontology highlight
ABSTRACT:
SUBMITTER: Cerasoli DM
PROVIDER: S-EPMC2192186 | biostudies-other | 1995 Nov
REPOSITORIES: biostudies-other
Cerasoli D M DM Riley M P MP Shih F F FF Caton A J AJ
The Journal of experimental medicine 19951101 5
We have analyzed the genetic basis for T cell recognition of an endogenous major histocompatibility complex class II-restricted self peptide. Transgenic mice expressing the influenza virus PR8 hemagglutinin I-Ed-restricted determinant S1 (HA Tg mice) mediate negative selection of PR8 S1-specific T cells, but respond to immunization with a virus containing a closely related analogue, S1(K113). Sequence analysis of S1(K113)-specific T cell receptors (TCR) from nontransgenic mice revealed a dominan ...[more]