Ontology highlight
ABSTRACT:
SUBMITTER: Cole BC
PROVIDER: S-EPMC2192318 | biostudies-other | 1996 Mar
REPOSITORIES: biostudies-other
The Journal of experimental medicine 19960301 3
Mycoplasma arthritidis, an agent of chronic proliferative arthritis of rodents, secretes a potent soluble superantigen, MAM, that is active for both murine and human T and B lymphocytes. We now report the complete nucleotide and amino acid sequence of MAM and show it to be distinct from other proteins and not closely related phylogenetically to other superantigens. Two functional domains on MAM are identified based on the ability of peptides encompassing these regions to inhibit lymphocyte proli ...[more]