Ontology highlight
ABSTRACT:
SUBMITTER: Zarek PE
PROVIDER: S-EPMC2200810 | biostudies-other | 2008 Jan
REPOSITORIES: biostudies-other
Zarek Paul E PE Huang Ching-Tai CT Lutz Eric R ER Kowalski Jeanne J Horton Maureen R MR Linden Joel J Drake Charles G CG Powell Jonathan D JD
Blood 20071001 1
Tissue-derived adenosine, acting via the adenosine A(2A) receptor (A(2A)R), is emerging as an important negative regulator of T-cell function. In this report, we demonstrate that A(2A)R stimulation not only inhibits the generation of adaptive effector T cells but also promotes the induction of adaptive regulatory T cells. In vitro, antigen recognition in the setting of A(2A)R engagement induces T-cell anergy, even in the presence of costimulation. T cells initially stimulated in the presence of ...[more]