Ontology highlight
ABSTRACT:
SUBMITTER: Lauring J
PROVIDER: S-EPMC2200833 | biostudies-other | 2008 Jan
REPOSITORIES: biostudies-other
Lauring Josh J Abukhdeir Abde M AM Konishi Hiroyuki H Garay Joseph P JP Gustin John P JP Wang Qiuju Q Arceci Robert J RJ Matsui William W Park Ben Ho BH
Blood 20071017 2
Multiple myeloma (MM) is an incurable hematologic malignancy characterized by recurrent chromosomal translocations. Patients with t(4;14)(p16;q32) are the worst prognostic subgroup in MM, although the basis for this poor prognosis is unknown. The t(4;14) is unusual in that it involves 2 potential target genes: fibroblast growth factor receptor 3 (FGFR3) and multiple myeloma SET domain (MMSET). MMSET is universally overexpressed in t(4;14) MM, whereas FGFR3 expression is lost in one-third of case ...[more]