AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum.
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ABSTRACT:
SUBMITTER: Lygren B
PROVIDER: S-EPMC2247390 | biostudies-other | 2007 Nov
REPOSITORIES: biostudies-other
Publications
AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum.
Lygren Birgitte B Carlson Cathrine Rein CR Santamaria Katja K Lissandron Valentina V McSorley Theresa T Litzenberg Jessica J Lorenz Dorothea D Wiesner Burkhard B Rosenthal Walter W Zaccolo Manuela M Taskén Kjetil K Klussmann Enno E
EMBO reports 20070928 11
The beta-adrenergic receptor/cyclic AMP/protein kinase A (PKA) signalling pathway regulates heart rate and contractility. Here, we identified a supramolecular complex consisting of the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2), its negative regulator phospholamban (PLN), the A-kinase anchoring protein AKAP18delta and PKA. We show that AKAP18delta acts as a scaffold that coordinates PKA phosphorylation of PLN and the adrenergic effect on Ca(2+) re-uptake. Inhibition of the compartmentalizatio ...[more]
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