Plasma serotonin levels are normal in pulmonary arterial hypertension.
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ABSTRACT:
SUBMITTER: Lederer DJ
PROVIDER: S-EPMC2267916 | biostudies-other | 2008
REPOSITORIES: biostudies-other
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Plasma serotonin levels are normal in pulmonary arterial hypertension.
Lederer David J DJ Horn Evelyn M EM Rosenzweig Erika B EB Karmally Wahida W Jahnes Megan M Barst Robyn J RJ Kawut Steven M SM
Pulmonary pharmacology & therapeutics 20070212 1
Serotonin (5-HT) has been implicated in the pathogenesis of pulmonary arterial hypertension (PAH). We hypothesized that plasma 5-HT would be elevated in PAH related to associated conditions. We performed a prospective cohort study of 21 patients with PAH undergoing initial right heart catheterization and 6 healthy controls. Platelet-free plasma 5-HT levels were similar in patients with idiopathic PAH, PAH related to associated conditions, and healthy controls. Higher 5-HT levels correlated with ...[more]
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