Ontology highlight
ABSTRACT:
SUBMITTER: Speiser DE
PROVIDER: S-EPMC2268830 | biostudies-other | 2008 Mar
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20080304 10
Human cancer vaccines are often prepared with altered "analog" or "heteroclitic" antigens that have been optimized for HLA class I binding, resulting in enhanced immunogenicity. Here, we take advantage of CpG oligodeoxynucleotides as powerful vaccine adjuvants and demonstrate the induction of high T cell frequencies in melanoma patients, despite the use of natural (unmodified) tumor antigenic peptide. Compared with vaccination with analog peptide, natural peptide induced T cell frequencies that ...[more]