Ontology highlight
ABSTRACT:
SUBMITTER: Shimazaki M
PROVIDER: S-EPMC2271007 | biostudies-other | 2008 Feb
REPOSITORIES: biostudies-other
Shimazaki Masashi M Nakamura Kazuto K Kii Isao I Kashima Takeshi T Amizuka Norio N Li Minqi M Saito Mitsuru M Fukuda Keiichi K Nishiyama Takashi T Kitajima Satoshi S Saga Yumiko Y Fukayama Masashi M Sata Masataka M Kudo Akira A
The Journal of experimental medicine 20080121 2
Acute myocardial infarction (AMI) is a common and lethal heart disease, and the recruitment of fibroblastic cells to the infarct region is essential for the cardiac healing process. Although stiffness of the extracellular matrix in the infarct myocardium is associated with cardiac healing, the molecular mechanism of cardiac healing is not fully understood. We show that periostin, which is a matricellular protein, is important for the cardiac healing process after AMI. The expression of periostin ...[more]