Ontology highlight
ABSTRACT:
SUBMITTER: Odeberg J
PROVIDER: S-EPMC228288 | biostudies-other | 1995 Jul
REPOSITORIES: biostudies-other
Odeberg J J Yun Z Z Sönnerborg A A Uhlén M M Lundeberg J J
Journal of clinical microbiology 19950701 7
In the present study, we used a semiautomated solid-phase direct sequencing method to analyze sequence diversity and variation of the hypervariable E2/NS1 region in the hepatitis C virus (HCV) genome in isolates from patients seropositive for HCV. A total of 24 isolates of various origins were sequenced. Six of the patients, not subject to any antiviral therapy, were monitored longitudinally, and rapid sequence variations were observed over a period of 14 months. The nucleotide change rate was f ...[more]