Ontology highlight
ABSTRACT:
SUBMITTER: Williams BC
PROVIDER: S-EPMC2289567 | biostudies-other | 1992 Aug
REPOSITORIES: biostudies-other
Williams B C BC Karr T L TL Montgomery J M JM Goldberg M L ML
The Journal of cell biology 19920801 4
Mutations in the gene l(1)zw10 disrupt the accuracy of chromosome segregation in a variety of cell types during the course of Drosophila development. Cytological analysis of mutant larval brain neuroblasts shows very high levels of aneuploid cells. Many anaphase figures are aberrant, the most frequent abnormality being the presence of lagging chromosomes that remain in the vicinity of the metaphase plate when the other chromosomes have migrated toward the spindle poles. Finally, the centromeric ...[more]