Ontology highlight
ABSTRACT:
SUBMITTER: Murphy E
PROVIDER: S-EPMC2291141 | biostudies-other | 2008 Apr
REPOSITORIES: biostudies-other
Murphy Eain E Vanícek Jirí J Robins Harlan H Shenk Thomas T Levine Arnold J AJ
Proceedings of the National Academy of Sciences of the United States of America 20080331 14
A quantitative algorithm was developed and applied to predict target genes of microRNAs encoded by herpesviruses. Although there is almost no conservation among microRNAs of different herpesvirus subfamilies, a common pattern of regulation emerged. The algorithm predicts that herpes simplex virus 1, human cytomegalovirus, Epstein-Barr virus, and Kaposi's sarcoma-associated herpesvirus all employ microRNAs to suppress expression of their own genes, including their immediate-early genes. In the ca ...[more]