Idiopathic hypertrophic cranial pachymeningitis treated by oral methotrexate: a case report and review of literature.
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ABSTRACT: Idiopathic hypertrophic cranial pachymeningitis (IHCP) is a rare clinical entity, characterized by a chronic inflammation causing thickening of the dura. Adequate therapeutic management is still a matter of debate. We present a patient with an IHCP, non-responsive to corticotherapy. Oral methotrexate was introduced (12.5 mg weekly) and total remission was observed after 6 weeks, both clinically and after neuro-imaging. We conclude that methotrexate can be effective and a therapeutical option in patients with IHCP who are resistant to corticotherapy or present major side-effects of chronic corticosteroids use.
SUBMITTER: Bosman T
PROVIDER: S-EPMC2292418 | biostudies-other | 2008 May
REPOSITORIES: biostudies-other
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