Ontology highlight
ABSTRACT:
SUBMITTER: Lin D
PROVIDER: S-EPMC2293081 | biostudies-other | 2008 May
REPOSITORIES: biostudies-other
Molecular and cellular biology 20080303 9
Translational repressors, increasing evidence suggests, participate in the regulation of protein synthesis at the synapse, thus providing a basis for the long-term plastic modulation of synaptic strength. Dendritic BC1 RNA is a non-protein-coding RNA that represses translation at the level of initiation. However, the molecular mechanism of BC1 repression has remained unknown. Here we identify the catalytic activity of eukaryotic initiation factor 4A (eIF4A), an ATP-dependent RNA helicase, as a t ...[more]