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A Mycobacterium tuberculosis IS6110 preferential locus (ipl) for insertion into the genome.

ABSTRACT: A 267-nucleotide Mycobacterium tuberculosis genomic sequence (ipl, the IS6110 preferential locus) which can harbor the insertion sequence IS6110 at six alternative locations has been identified in some three-quarters of the isolates tested. Only one IS6110 copy was observed at this locus in the ipl::IS6110(+)-containing isolates tested, and all insertions had the same orientation. The implications of this finding for IS6110 fingerprint typing methods is discussed in this work.

SUBMITTER: Fang Z

PROVIDER: S-EPMC229605 | biostudies-other | 1997 Feb

REPOSITORIES: biostudies-other

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A Mycobacterium tuberculosis IS6110 preferential locus (ipl) for insertion into the genome.

Fang Z Z Forbes K J KJ

Journal of clinical microbiology 19970201 2

A 267-nucleotide Mycobacterium tuberculosis genomic sequence (ipl, the IS6110 preferential locus) which can harbor the insertion sequence IS6110 at six alternative locations has been identified in some three-quarters of the isolates tested. Only one IS6110 copy was observed at this locus in the ipl::IS6110(+)-containing isolates tested, and all insertions had the same orientation. The implications of this finding for IS6110 fingerprint typing methods is discussed in this work. ...[more]

PMID: 9003621

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Phospholipase region of Mycobacterium tuberculosis is a preferential locus for IS6110 transposition.

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