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Structure and function of the long terminal repeats of feline leukemia viruses derived from naturally occurring acute myeloid leukemias in cats.


ABSTRACT: Long terminal repeats of feline leukemia viruses cloned from feline acute myeloid leukemias frequently contained direct repeats of 40 to 74 bp in the upstream region of the enhancer (URE). The repetitive URE conferred an enhancer function upon gene expression in myeloid cells, suggesting its association with tumorigenic potential in myeloid cells.

SUBMITTER: Nishigaki K 

PROVIDER: S-EPMC230298 | biostudies-other | 1997 Dec

REPOSITORIES: biostudies-other

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Structure and function of the long terminal repeats of feline leukemia viruses derived from naturally occurring acute myeloid leukemias in cats.

Nishigaki K K   Okuda M M   Endo Y Y   Watari T T   Tsujimoto H H   Hasegawa A A  

Journal of virology 19971201 12


Long terminal repeats of feline leukemia viruses cloned from feline acute myeloid leukemias frequently contained direct repeats of 40 to 74 bp in the upstream region of the enhancer (URE). The repetitive URE conferred an enhancer function upon gene expression in myeloid cells, suggesting its association with tumorigenic potential in myeloid cells. ...[more]

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