Ontology highlight
ABSTRACT:
SUBMITTER: Thakur S
PROVIDER: S-EPMC231769 | biostudies-other | 1997 Jan
REPOSITORIES: biostudies-other
Molecular and cellular biology 19970101 1
Inherited mutations in BRCA1 confer susceptibility to breast and ovarian neoplasms. However, the function of BRCA1 and the role of BRCA1 in noninherited cancer remain unknown. Characterization of alternately spliced forms of BRCA1 may identify functional regions; thus, we constructed expression vectors of BRCA1 and a splice variant lacking exon 11, designated BRCA1 delta 672-4095. Immunofluorescence studies indicate nuclear localization of BRCA1 but cytoplasmic localization of BRCA1 delta 672-40 ...[more]