Ontology highlight
ABSTRACT:
SUBMITTER: Harvey AJ
PROVIDER: S-EPMC232135 | biostudies-other | 1997 May
REPOSITORIES: biostudies-other
Harvey A J AJ Bidwai A P AP Miller L K LK
Molecular and cellular biology 19970501 5
A family of baculovirus inhibitor-of-apoptosis (IAP) genes is present in mammals, insects, and baculoviruses, but the mechanism by which they block apoptosis is unknown. We have identified a protein encoded by the Drosophila mod(mdg4) gene which bound to the baculovirus IAPs. This protein induced rapid apoptosis in insect cells, and consequently we have named it Doom. Baculovirus IAPs and P35, an inhibitor of aspartate-specific cysteine proteases, blocked Doom-induced apoptosis. The carboxyl ter ...[more]