Ontology highlight
ABSTRACT:
SUBMITTER: Horiuchi J
PROVIDER: S-EPMC232175 | biostudies-other | 1997 Jun
REPOSITORIES: biostudies-other
Horiuchi J J Silverman N N Piña B B Marcus G A GA Guarente L L
Molecular and cellular biology 19970601 6
The ADA genes encode factors which are proposed to function as transcriptional coactivators. Here we describe the cloning, sequencing, and initial characterization of a novel ADA gene, ADA1. Similar to the previously isolated ada mutants, ada1 mutants display decreases in transcription from various reporters. Furthermore, ADA1 interacts with the other ADAs in the ADA/GCN5 complex as demonstrated by partial purification of the complex and immunoprecipitation experiments. We estimate that the comp ...[more]