Mathematical models of the VEGF receptor and its role in cancer therapy.
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ABSTRACT:
SUBMITTER: Alarcon T
PROVIDER: S-EPMC2359839 | biostudies-other | 2007 Apr
REPOSITORIES: biostudies-other
Publications
Mathematical models of the VEGF receptor and its role in cancer therapy.
Alarcón Tomás T Page Karen M KM
Journal of the Royal Society, Interface 20070401 13
We present an analysis of a stochastic model of the vascular endothelial growth factor (VEGF) receptor. This analysis addresses the contribution of ligand-binding-induced oligomerization, activation of src-homology 2 domain-carrying kinases and receptor internalization in the overall behaviour of the VEGF/VEGF receptor (VEGFR) system. The analysis is based upon a generalization of a Wentzel-Kramers-Brillouin (WKB) approximation of the solution of the corresponding master equation. We predict tha ...[more]
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