Ontology highlight
ABSTRACT:
SUBMITTER: Arstikaitis P
PROVIDER: S-EPMC2366842 | biostudies-other | 2008 May
REPOSITORIES: biostudies-other
Arstikaitis Pamela P Gauthier-Campbell Catherine C Carolina Gutierrez Herrera Rosario R Huang Kun K Levinson Joshua N JN Murphy Timothy H TH Kilimann Manfred W MW Sala Carlo C Colicos Michael A MA El-Husseini Alaa A
Molecular biology of the cell 20080220 5
Dendritic filopodia are thought to participate in neuronal contact formation and development of dendritic spines; however, molecules that regulate filopodia extension and their maturation to spines remain largely unknown. Here we identify paralemmin-1 as a regulator of filopodia induction and spine maturation. Paralemmin-1 localizes to dendritic membranes, and its ability to induce filopodia and recruit synaptic elements to contact sites requires protein acylation. Effects of paralemmin-1 on syn ...[more]