Ontology highlight
ABSTRACT:
SUBMITTER: Yang Z
PROVIDER: S-EPMC2373443 | biostudies-other | 2002 Feb
REPOSITORIES: biostudies-other
Yang Zhiru Z Zhang Hailong H Hung Hui-Chi HC Kuo Chen-Chin CC Tsai Li-Chu LC Yuan Hanna S HS Chou Wei-Yuan WY Chang Gu-Gang GG Tong Liang L
Protein science : a publication of the Protein Society 20020201 2
Malic enzymes are widely distributed in nature, and have important biological functions. They catalyze the oxidative decarboxylation of malate to produce pyruvate and CO(2) in the presence of divalent cations (Mg(2+), Mn(2+)). Most malic enzymes have a clear selectivity for the dinucleotide cofactor, being able to use either NAD(+) or NADP(+), but not both. Structural studies of the human mitochondrial NAD(+)-dependent malic enzyme established that malic enzymes belong to a new class of oxidativ ...[more]