Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breast cancer.
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ABSTRACT:
SUBMITTER: Grothey A
PROVIDER: S-EPMC2374674 | biostudies-other | 2000 Oct
REPOSITORIES: biostudies-other
Publications
Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breast cancer.
Grothey A A Hashizume R R Sahin A A AA McCrea P D PD
British journal of cancer 20001001 7
Loss of hormone receptor (HR) status in breast carcinomas is associated with increased tumour cell motility and invasiveness. In an immunohistological study of 58 primary breast cancers, oestrogen (ER) and progesterone (PR) receptor levels were inversely correlated with the expression of fascin, an actin-bundling protein associated with cell motility (P< 0.0001 and P = 0.0019, respectively). In addition, fascin was preferentially expressed in non-diploid tumours (P = 0.03). In summary, the upreg ...[more]
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