Ontology highlight
ABSTRACT:
SUBMITTER: Bamford NS
PROVIDER: S-EPMC2394729 | biostudies-other | 2008 Apr
REPOSITORIES: biostudies-other
Bamford Nigel S NS Zhang Hui H Joyce John A JA Scarlis Christine A CA Hanan Whitney W Wu Nan-Ping NP André Véronique M VM Cohen Rachel R Cepeda Carlos C Levine Michael S MS Harleton Erin E Sulzer David D
Neuron 20080401 1
Addiction-associated behaviors such as drug craving and relapse are hypothesized to result from synaptic changes that persist long after withdrawal and are renormalized by drug reinstatement, although such chronic synaptic effects have not been identified. We report that exposure to the dopamine releaser methamphetamine for 10 days elicits a long-lasting (>4 month) depression at corticostriatal terminals that is reversed by methamphetamine readministration. Both methamphetamine-induced chronic p ...[more]