Ontology highlight
ABSTRACT:
SUBMITTER: Minter-Dykhouse K
PROVIDER: S-EPMC2396806 | biostudies-other | 2008 Jun
REPOSITORIES: biostudies-other
Minter-Dykhouse Katherine K Ward Irene I Huen Michael S Y MS Chen Junjie J Lou Zhenkun Z
The Journal of cell biology 20080526 5
The importance of the DNA damage response (DDR) pathway in development, genomic stability, and tumor suppression is well recognized. Although 53BP1 and MDC1 have been recently identified as critical upstream mediators in the cellular response to DNA double-strand breaks, their relative hierarchy in the ataxia telangiectasia mutated (ATM) signaling cascade remains controversial. To investigate the divergent and potentially overlapping functions of MDC1 and 53BP1 in the ATM response pathway, we ge ...[more]